Chapter 37 Introduction to Section 6

This handbook addresses a growing list of challenges faced by regions and cities in the Pacific;Rim, drawing connections around the what, why, and how questions that are fundamental;to sustainable development policies and planning practices. These include the connection;between cities and surrounding landscapes, across different boundaries and scales; the persistence;of environmental and development inequities; and the growing impacts of global;climate change, including how physical conditions and social implications are being anticipated;and addressed. Building upon localized knowledge and contextualized experiences,;this edited collection brings attention to place-;based;approaches across the Pacific Rim and;makes an important contribution to the scholarly and practical understanding of sustainable;urban development models that have mostly emerged out of the Western experiences. Nine;sections, each grounded in research, dialogue, and collaboration with practical examples and;analysis, focus on a theme or dimension that carries critical impacts on a holistic vision of city-;landscape;development, such as resilient communities, ecosystem services and biodiversity,;energy, water, health, and planning and engagement.;This international edited collection will appeal to academics and students engaged in;research involving landscape architecture, architecture, planning, public policy, law, urban;studies, geography, environmental science, and area studies. It also informs policy makers,;professionals, and advocates of actionable knowledge and adoptable ideas by connecting;those issues with the Sustainable Development Goals (SDGs);of the United Nations. The;collection of writings presented in this book speaks to multiyear collaboration of scholars;through the APRU Sustainable Cities and Landscapes (SCL);Program and its global network,;facilitated by SCL Annual Conferences and involving more than 100 contributors;from more than 30 institutions

Coded Kalman Filtering Over Gaussian Channels with Feedback

This paper investigates the problem of zero-delay joint source-channel coding of a vector Gauss-Markov source over a multiple-input multiple-output (MIMO) additive white Gaussian noise (AWGN) channel with feedback. In contrast to the classical problem of causal estimation using noisy observations, we examine a system where the source can be encoded before transmission. An encoder, equipped with feedback of past channel outputs, observes the source state and encodes the information in a causal manner as inputs to the channel while adhering to a power constraint. The objective of the code is to estimate the source state with minimum mean square error at the infinite horizon. This work shows a fundamental theorem for two scenarios: for the transmission of an unstable vector Gauss-Markov source over either a multiple-input single-output (MISO) or a single-input multiple-output (SIMO) AWGN channel, finite estimation error is achievable if and only if the sum of logs of the unstable eigenvalues of the state gain matrix is less than the Shannon channel capacity. We prove these results by showing an optimal linear innovations encoder that can be applied to sources and channels of any dimension and analyzing it together with the corresponding Kalman filter decoder.Comment: Presented at 59th Allerton Conference on Communication, Control, and Computin

Chapter 37 Introduction to Section 6

This handbook addresses a growing list of challenges faced by regions and cities in the Pacific;Rim, drawing connections around the what, why, and how questions that are fundamental;to sustainable development policies and planning practices. These include the connection;between cities and surrounding landscapes, across different boundaries and scales; the persistence;of environmental and development inequities; and the growing impacts of global;climate change, including how physical conditions and social implications are being anticipated;and addressed. Building upon localized knowledge and contextualized experiences,;this edited collection brings attention to place-;based;approaches across the Pacific Rim and;makes an important contribution to the scholarly and practical understanding of sustainable;urban development models that have mostly emerged out of the Western experiences. Nine;sections, each grounded in research, dialogue, and collaboration with practical examples and;analysis, focus on a theme or dimension that carries critical impacts on a holistic vision of city-;landscape;development, such as resilient communities, ecosystem services and biodiversity,;energy, water, health, and planning and engagement.;This international edited collection will appeal to academics and students engaged in;research involving landscape architecture, architecture, planning, public policy, law, urban;studies, geography, environmental science, and area studies. It also informs policy makers,;professionals, and advocates of actionable knowledge and adoptable ideas by connecting;those issues with the Sustainable Development Goals (SDGs);of the United Nations. The;collection of writings presented in this book speaks to multiyear collaboration of scholars;through the APRU Sustainable Cities and Landscapes (SCL);Program and its global network,;facilitated by SCL Annual Conferences and involving more than 100 contributors;from more than 30 institutions

Reducing INDEL calling errors in whole genome and exome sequencing data

BACKGROUND: INDELs, especially those disrupting protein-coding regions of the genome, have been strongly associated with human diseases. However, there are still many errors with INDEL variant calling, driven by library preparation, sequencing biases, and algorithm artifacts. METHODS: We characterized whole genome sequencing (WGS), whole exome sequencing (WES), and PCR-free sequencing data from the same samples to investigate the sources of INDEL errors. We also developed a classification scheme based on the coverage and composition to rank high and low quality INDEL calls. We performed a large-scale validation experiment on 600 loci, and find high-quality INDELs to have a substantially lower error rate than low-quality INDELs (7% vs. 51%). RESULTS: Simulation and experimental data show that assembly based callers are significantly more sensitive and robust for detecting large INDELs (>5 bp) than alignment based callers, consistent with published data. The concordance of INDEL detection between WGS and WES is low (53%), and WGS data uniquely identifies 10.8-fold more high-quality INDELs. The validation rate for WGS-specific INDELs is also much higher than that for WES-specific INDELs (84% vs. 57%), and WES misses many large INDELs. In addition, the concordance for INDEL detection between standard WGS and PCR-free sequencing is 71%, and standard WGS data uniquely identifies 6.3-fold more low-quality INDELs. Furthermore, accurate detection with Scalpel of heterozygous INDELs requires 1.2-fold higher coverage than that for homozygous INDELs. Lastly, homopolymer A/T INDELs are a major source of low-quality INDEL calls, and they are highly enriched in the WES data. CONCLUSIONS: Overall, we show that accuracy of INDEL detection with WGS is much greater than WES even in the targeted region. We calculated that 60X WGS depth of coverage from the HiSeq platform is needed to recover 95% of INDELs detected by Scalpel. While this is higher than current sequencing practice, the deeper coverage may save total project costs because of the greater accuracy and sensitivity. Finally, we investigate sources of INDEL errors (for example, capture deficiency, PCR amplification, homopolymers) with various data that will serve as a guideline to effectively reduce INDEL errors in genome sequencing

Clinical efficacy and safety of lamotrigine monotherapy in newly diagnosed pediatric patients with epilepsy

Purpose : To verify the efficacy and safety of lamotrigine (LTG) monotherapy in newly diagnosed children with epilepsy. Methods : We prospectively enrolled 148 children who had undergone LTG monotherapy at our institution between September 2002 and June 2009. Twenty-nine patients were excluded: 19 due to incomplete data and 10 were lost to follow up. The data of the remaining 119 patients was analyzed. Results : We enrolled 119 pediatric epilepsy patients (aged 2.8-19.3 years&#59; 66 males and 53 females) in this study. Out of 119 patients, 29 (25.2%) had generalized epilepsy and 90 (74.8%) had partial epilepsy. The responses of seizure reduction were as follows: Seizure freedom (no seizure attack for at least 6 months) in 87/111 (78.4%, n=111) patients&#59; partial response (reduced seizure frequency compared to baseline) in 13 (11.7%) patients&#59; and persistent seizure in 11 (9.9%) patients. The seizure freedom rate was in 81.6% in patients with partial seizure (75.9% for complex partial seizure and 90.9% for benign rolandic epilepsy) and 44.8% in patients with generalized epilepsy (30.0% for absence seizure, 35.7% for juvenile myoclonic epilepsy patients, and 100.0% for idiopathic generalized epilepsy patients). Adverse reactions were reported in 17 (14.3%) patients, and 8 patients (6.7%) discontinued LTG because of rash and tic. No patient experienced severe adverse reaction such as Stevens-Johnson syndrome. Conclusion : LTG showed excellent therapeutic response and had few significant adverse effects. Our findings report may contribute in promoting the use of LTG monotherapy in epileptic children

Comparison of Factors Associated with Atypical Symptoms in Younger and Older Patients with Acute Coronary Syndromes

Patients with acute coronary syndromes (ACS) who are accompanied by atypical symptoms are frequently misdiagnosed and under-treated. This study was conducted to examine and compare the factors associated with atypical symptoms other than chest pain in younger (<70 yr) and older (≥70 yr) patients with first-time ACS. Data were obtained from the electronic medical records of the patients (n=931) who were newly diagnosed as ACS and hospitalized from 2005 to 2006. The 7.8% (n=49) of the younger patients and 13.4% (n=41) of the older patients were found to have atypical symptoms. Older patients were more likely to complain of indigestion or abdominal discomfort (P=0.019), nausea and/or vomiting (P=0.040), and dyspnea (P<0.001), and less likely to have chest pain (P=0.007) and pains in the arm and shoulder (P=0.018). A logistic regression analysis showed that after adjustment made for the gender and ACS type, diabetes and hyperlipidemia significantly predicted atypical symptoms in the younger patients. In the older patients, the co-morbid conditions such as stroke or chronic obstructive pulmonary disease were positive predictors. Health care providers need to have an increased awareness of possible presence of ACS in younger persons with diabetes and older persons with chronic concomitant diseases when evaluating patients with no chest pain

Enantiomeric Discrimination by Surface- Enhanced Raman Scattering- Chiral Anisotropy of Chiral Nanostructured Gold Films

A surface- enhanced Raman scattering- chiral anisotropy (SERS- ChA) effect is reported that combines chiral discrimination and surface Raman scattering enhancement on chiral nanostructured Au films (CNAFs) equipped in the normal Raman scattering Spectrometer. The CNAFs provided remarkably higher enhancement factors of Raman scattering (EFs) for particular enantiomers, and the SERS intensity was proportional to the enantiomeric excesses (ee) values. Except for molecules with mesomeric species, all of the tested enantiomers exhibited high SERS- ChA asymmetry factors (g), ranging between 1.34 and 1.99 regardless of polarities, sizes, chromophores, concentrations and ee. The effect might be attributed to selective resonance coupling between the induced electric and magnetic dipoles associated with enantiomers and chiral plasmonic modes of CNAFs.Absolution by SERS: A surface- enhanced Raman scattering chiral anisotropy effect is presented that combines chiral discrimination and surface Raman scattering enhancement on chiral nanostructured Au films. It is applied in the normal Raman scattering system to identify the absolute configuration and composition of enantiomers, overcoming disadvantages of polarimeter systems and chromatography.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/156470/3/ange202006486_am.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156470/2/ange202006486.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156470/1/ange202006486-sup-0001-misc_information.pd